Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication
about
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesisCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisReplication of Structured DNA and its implication in epigenetic stabilityStructure and mechanism of human DNA polymerase ηThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionBiochemical analysis of DNA polymerase η fidelity in the presence of replication protein AMicrosatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomesDNA secondary structure at chromosomal fragile sites in human disease.Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNADNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instabilityPhosphorylated Rad18 directs DNA polymerase η to sites of stalled replicationSpartan deficiency causes genomic instability and progeroid phenotypes.Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability.Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability.Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stabilityUnlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae.DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome proteinMechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis.Y-family DNA polymerases and their role in tolerance of cellular DNA damage.DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.Biochemical analysis of active site mutations of human polymerase ηDNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.DNA polymerases and cancer.The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.PrimPol-A new polymerase on the block.A role for DNA polymerase θ in the timing of DNA replication.Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells.
P2860
Q24298314-A6D139D0-CB90-41D0-BAB0-9DE2DD1F9001Q26825040-90584CB6-3E72-4199-807F-804AAF90F6B4Q26992309-C634D17E-5BB4-4CDF-97AD-E09A509EE170Q27662730-4DFE85DA-3A17-4314-823F-57662BD69996Q28303222-A77B38C2-FC14-4C4E-9028-8DA42B522C2DQ28538764-4F362F46-5064-4245-8289-844DE7088760Q28540820-27784BB3-61B2-4FE1-9E16-97F7D1A1A20AQ30300009-49746ED7-318C-4DA0-B03B-A006F8FC15F9Q33605965-D02A2B24-12DE-4856-A134-47ED0B20CFE1Q33997247-4B9FDCDE-F368-435B-9278-59B62A74EA2DQ34067829-0177F3D1-7749-44CF-A819-736EDDB448B2Q34368618-59449DAE-1697-4D03-99EB-58FD243D8D36Q34722436-48554AA6-D8A0-46FE-8752-3EC1977D76CBQ35759995-C8CED269-ADD7-4A9C-9C7A-AEE51964C91AQ35780144-726F5C3B-2F32-4AC3-8B4B-E96DD49CD4A8Q35989743-427AFFD0-AA89-4691-B1E4-5A64FCD74D26Q36035857-F3B05203-45C0-4530-9FBB-0EC02C0C5E8EQ36296857-DD4519E0-55FC-49B7-B7EB-58C605662DC1Q36415115-B5245295-A63E-4A92-AFEC-74E9851238C2Q36452037-1468AECC-EED0-4A88-8FAD-94000153A4D5Q36517968-0885F5BC-17FE-45C5-A41E-A922DDAAFF1DQ36553152-5B28FC12-9323-477C-BDB3-2E833B523845Q36646991-98951B89-FC00-42D8-8CD0-8F74BB432C38Q36770665-DE6B9CFD-E491-431E-AFA2-DAD8E855C120Q36778894-C06ACFFE-819B-4964-8474-831B77034200Q36804077-04D3FD62-E5B4-42ED-9FF4-A1D6BE25B3ABQ36893377-612D4AC8-D1D4-4420-8F14-961DA1E9738CQ37061484-0BF22098-B798-4BE4-8A61-82C6F7CC799AQ37084895-E964999F-DD0D-477C-B725-283E1D2139C6Q37355956-B6D9ED87-4058-435E-8B95-A87213CD0907Q37396238-2D57AE67-822B-4F7E-B04C-1A3CB5F2DD0BQ37416977-B1119417-1B61-4095-9122-88B2C3AB2431Q37432824-3608E5BD-AE13-4C4B-8FD4-AC64072CFF75Q37504432-872111AE-D14C-4A83-B0D8-145097A39810Q37618680-2E78EAFD-6F07-48E8-9C89-2BF837FB736BQ38063711-5F8DC851-1135-43FA-819F-E4EA0E3E3F08Q38866687-1172FB78-481A-4552-91B4-E77D1BE66949Q38978675-6CD50F71-86D5-4F5F-BCD8-91965932094CQ39031967-36C27966-4A46-433A-915B-3574869A385DQ39061225-8ABA68B5-1BFA-4166-AB97-CE1FEC1013E8
P2860
Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Human DNA polymerase eta is re ...... ng unperturbed DNA replication
@en
type
label
Human DNA polymerase eta is re ...... ng unperturbed DNA replication
@en
prefLabel
Human DNA polymerase eta is re ...... ng unperturbed DNA replication
@en
P2093
P2860
P356
P1476
Human DNA polymerase eta is re ...... ng unperturbed DNA replication
@en
P2093
Christophe Cazaux
François Boudsocq
Jean-Sébastien Hoffmann
Laurie Rey
Nadine Puget
Raymond J Monnat
P2860
P304
P356
10.1128/MCB.00115-09
P407
P577
2009-04-20T00:00:00Z