DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability - Wikidata - wikimedia - TriplyDB

DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

http://www.wikidata.org/entity/Q34067829

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Promiscuous DNA synthesis by human DNA polymerase θ Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ Role of DNA polymerase κ in the maintenance of genomic stability DNA Damage and Pulmonary Hypertension DNA polymerase θ (POLQ), double-strand break repair, and cancer Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells Mechanism of suppression of chromosomal instability by DNA polymerase POLQ Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.Drugging the Cancers Addicted to DNA Repair.Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair Error-Prone Repair of DNA Double-Strand Breaks.Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.Human DNA polymerase θ grasps the primer terminus to mediate DNA repair Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Lethal mutagenesis: targeting the mutator phenotype in cancer.Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites.Impact of the DNA polymerase Theta on the DNA replication program.A role for human homologous recombination factors in suppressing microhomology-mediated end joining DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.Linking DNA polymerase theta structure and function in health and disease DNA polymerase POLQ and cellular defense against DNA damage.Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining DNA polymerases and cancer.DNA damage tolerance: a double-edged sword guarding the genome DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes.A novel POLH mutation causes XP-V disease and XP-V tumor proneness may involve imbalance of numerous DNA polymerases.The DNA resection protein CtIP promotes mammary tumorigenesis.Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides Stop pulling my strings - what telomeres taught us about the DNA damage response.Translesion DNA synthesis in the context of cancer research.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.Mouse models of DNA polymerases.Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.A role for DNA polymerase θ in the timing of DNA replication.Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells.Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

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DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

http://www.wikidata.org/entity/Q34067829

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-sg

2010年學術文章

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name

DNA polymerase theta up-regula ...... d promotes genetic instability

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DNA polymerase theta up-regula ...... d promotes genetic instability

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DNA polymerase theta up-regula ...... d promotes genetic instability

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type

label

DNA polymerase theta up-regula ...... d promotes genetic instability

@ast

DNA polymerase theta up-regula ...... d promotes genetic instability

@en

DNA polymerase theta up-regula ...... d promotes genetic instability

@nl

prefLabel

DNA polymerase theta up-regula ...... d promotes genetic instability

@ast

DNA polymerase theta up-regula ...... d promotes genetic instability

@en

DNA polymerase theta up-regula ...... d promotes genetic instability

@nl

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PNAS.0910759107

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Proceedings of the National Academy of Sciences of the United States of America

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DNA polymerase theta up-regula ...... d promotes genetic instability

@en

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Alastair Thompson

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Alice Machado-Silva

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Anne Bieth

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Anne-Laure Martin

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Bernd Kaina

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Catherine Gentil

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Christophe Cazaux

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Claire Leduc

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Eddy Magdeleine

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Elena Lam

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P2860

POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

High-efficiency bypass of DNA damage by human DNA polymerase Q

Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

Cyclin E and survival in patients with breast cancer.

Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis

The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

Phenotype-based identification of mouse chromosome instability mutants

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13390-13395

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scholarly article

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10.1073/PNAS.0910759107

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30

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107

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Richard Dean Wood

Thomas Filleron

Jean-Christophe Bourdon

A Fernandez-Vidal

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2010-07-12T00:00:00Z

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45167350

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20624954

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2922118

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