Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin.
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Insights into arbovirus evolution and adaptation from experimental studiesViral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide DepletionViral quasispecies evolutionReassessing Biological Threats: Implications for Cooperative Mitigation StrategiesStructural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.Counteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic TreatmentStructure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to RibavirinA Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-EscapeStructural basis for active site closure by the poliovirus RNA-dependent RNA polymeraseStructures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contactsDoes mutational robustness inhibit extinction by lethal mutagenesis in viral populations?Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymeraseCoronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeuticsThe RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus familySequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in MosquitoesVariable mutation rates as an adaptive strategy in replicator populations.Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Genomic mutation rates that neutralize adaptive evolution and natural selectionFidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.Genomic evolution of vesicular stomatitis virus strains with differences in adaptability.Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus phi6Generation and characterization of influenza A viruses with altered polymerase fidelity.Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population.Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelityUltra-deep pyrosequencing of partial surface protein genes from infectious Salmon Anaemia virus (ISAV) suggest novel mechanisms involved in transition to virulence.Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency.Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection.Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelityPoint mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivoEffective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3D geneA Polymerase mechanism-based strategy for viral attenuation and vaccine development.Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA.Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple MutagensEffect of reaction conditions and 3AB on the mutation rate of poliovirus RNA-dependent RNA polymerase in a alpha-complementation assay.Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect modelsDynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence.Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.
P2860
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P2860
Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Determinants of RNA-dependent ...... uced sensitivity to ribavirin.
@en
type
label
Determinants of RNA-dependent ...... uced sensitivity to ribavirin.
@en
prefLabel
Determinants of RNA-dependent ...... uced sensitivity to ribavirin.
@en
P2093
P2860
P50
P356
P1433
P1476
Determinants of RNA-dependent ...... uced sensitivity to ribavirin.
@en
P2093
Eric D Smidansky
Jamie J Arnold
Macarena Sierra
P2860
P304
12346-12355
P356
10.1128/JVI.01297-08
P407
P577
2008-10-01T00:00:00Z