Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression. - Wikidata - wikimedia - TriplyDB

Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.

Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.

http://www.wikidata.org/entity/Q41461116

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The interplay of histone modifications - writers that read Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.RE-IIBP Methylates H3K79 and Induces MEIS1-mediated Apoptosis via H2BK120 Ubiquitination by RNF20 DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.Getting down to the core of histone modifications.Histone methylation during neural development.Posttranslational modifications of human histone H3: an update.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.The upstreams and downstreams of H3K79 methylation by DOT1L.Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality.DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro.Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets.Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast.Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle.Enhanced SMAD1 Signaling Contributes to Impairments of Early Development in CFC-iPSCs.DOT1L and H3K79 Methylation in Transcription and Genomic Stability.TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L.

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Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.

http://www.wikidata.org/entity/Q41461116

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Human histone H3K79 methyltran ...... I to regulate gene expression.

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Human histone H3K79 methyltran ...... I to regulate gene expression.

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Human histone H3K79 methyltran ...... I to regulate gene expression.

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JBC.M112.384057

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Journal of Biological Chemistry

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Human histone H3K79 methyltran ...... I to regulate gene expression.

@en

P2093

Chang Seob Kwon

http://www.w3.org/2001/XMLSchema#string

Daeyoup Lee

http://www.w3.org/2001/XMLSchema#string

Dongsup Kim

http://www.w3.org/2001/XMLSchema#string

Hosuk Lee

http://www.w3.org/2001/XMLSchema#string

Inkyung Jung

http://www.w3.org/2001/XMLSchema#string

Keunsoo Kang

http://www.w3.org/2001/XMLSchema#string

Kwiwan Jeong

http://www.w3.org/2001/XMLSchema#string

Mirang Kim

http://www.w3.org/2001/XMLSchema#string

Seung-Kyoon Kim

http://www.w3.org/2001/XMLSchema#string

Yong Sung Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Model-based analysis of ChIP-Seq (MACS)

Crystal structure of the nucleosome core particle at 2.8 A resolution

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II

Histone modifications defining active genes persist after transcriptional and mitotic inactivation

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

TopHat: discovering splice junctions with RNA-Seq

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39698-39709

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10.1074/JBC.M112.384057

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47

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287

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2012-09-25T00:00:00Z

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23012353

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3501035

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