Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

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TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model

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Q58794179-D60BD947-2FD6-4E0D-B9CB-5767AD4C8AE5

P2860

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

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http://www.wikidata.org/entity/Q41473977

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

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2016年论文

@zh

2016年论文

@zh-cn

name

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

@en

type

Item

label

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

@en

prefLabel

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

@en

P1476

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor

@en

P2093

Gyorgy Snell

http://www.w3.org/2001/XMLSchema#string

Hidekazu Tokuhara

http://www.w3.org/2001/XMLSchema#string

Keiji Kusumoto

http://www.w3.org/2001/XMLSchema#string

Mitsuyo Kondo

http://www.w3.org/2001/XMLSchema#string

Ray Kanagawa

http://www.w3.org/2001/XMLSchema#string

Takanobu Kuroita

http://www.w3.org/2001/XMLSchema#string

Yasuhiro Imaeda

http://www.w3.org/2001/XMLSchema#string

Yoshiyuki Fukase

http://www.w3.org/2001/XMLSchema#string

Yumiko Kajimoto

http://www.w3.org/2001/XMLSchema#string

P2860

Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors

A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore

Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Direct renin inhibitors as a new therapy for hypertension

Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.

Molecular properties that influence the oral bioavailability of drug candidates.

Biotransformation reactions of five-membered aromatic heterocyclic rings.

Drugs targeting the renin-angiotensin-aldosterone system.

Clinical pharmacokinetics and pharmacodynamics of aliskiren.

P304

933-938

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scholarly article

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10.1021/ACSMEDCHEMLETT.6B00251

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P478

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Craig Behnke

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2016-09-12T00:00:00Z

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27774132

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P932

5066151

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Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

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P2860

P2860

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

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P1476

P2093

P2860

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P356

P433

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P50

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P698

P932

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P1433

P1476

P2093

P2860

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P31

P356

P433

P478

P50

P577

P698

P932