Biotransformation reactions of five-membered aromatic heterocyclic rings.
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Reactive metabolites in the biotransformation of molecules containing a furan ringRapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence"Click" reaction in conjunction with diazeniumdiolate chemistry: developing high-load nitric oxide donors.Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MS(n) techniques.Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptorsInactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug.Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitorsOvercoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position.SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives.Minimising the potential for metabolic activation in drug discovery.Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice.Neoclerodanes as atypical opioid receptor ligandsCopper-catalyzed arylation of heterocycle C-H bonds.Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis.Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuseSteroid/triterpenoid functional molecules based on "click chemistry".Metabolic activation in drug-induced liver injury.Idiosyncratic reactions and metabolism of sulfur-containing drugs.Furan oxidation based cross-linking: a new approach for the study and targeting of nucleic acid and protein interactions.Facile diverted synthesis of pyrrolidinyl triazoles using organotrifluoroborate: discovery of potential mPTP blockers.Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase.Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipinAdvances in synthetic approach to and antifungal activity of triazoles.Synthesis and antifungal activity of the novel triazole derivatives containing 1,2,3-triazole fragment.Direct access to triazole-olefins through catalytic cycloaddition of azides to unsaturated aldehydes.Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids.Cyclisation versus 1,1-Carboboration: Reactions of B(C6F5)3 with Propargyl Amides.Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics.Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 24 (FGE.24): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28...Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific...Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28 Flavouring Group Evaluation 24, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30Scientific Opinion on Flavouring Group Evaluation 21, Revision 2 (FGE.21Rev2): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30Scientific Opinion on Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30
P2860
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P2860
Biotransformation reactions of five-membered aromatic heterocyclic rings.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@ast
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@en
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@nl
type
label
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@ast
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@en
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@nl
prefLabel
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@ast
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@en
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@nl
P2093
P356
P1476
Biotransformation reactions of five-membered aromatic heterocyclic rings.
@en
P2093
Amit S Kalgutkar
Deepak K Dalvie
John P O'Donnell
R Scott Obach
S Cyrus Khojasteh-Bakht
P304
P356
10.1021/TX015574B
P577
2002-03-01T00:00:00Z