Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
about
The Janus kinases (Jaks)Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytesDifferences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptorPhosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domainInterferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor threeDirect binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinaseJAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal regionRegulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.The role of suppressors of cytokine signalling in human neoplasmsAn evolutionary conserved function of the JAK-STAT pathway in anti-dengue defenseImpact of alcohol on hepatitis C virus replication and interferon signalingThe human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptorsStat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiationThe type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor proteinThe type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transductionRole of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinasesAssociation of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphataseInterleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesPhosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptorInterferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinaseIdentification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathwayRegulation of STAT1 nuclear export by Jak1An incomplete program of cellular tyrosine phosphorylations induced by kinase-defective epidermal growth factor receptors.Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines.STAT signaling in the pathogenesis and treatment of cancerLatent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteinsRegulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathwaySTAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinaseJanus kinases: components of multiple signaling pathways.Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.Dual modulation of type I interferon response by bluetongue virus.Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling
P2860
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P2860
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
@en
type
label
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
@en
prefLabel
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
@en
P2093
P356
P1433
P1476
Interferon-induced nuclear signalling by Jak protein tyrosine kinases.
@en
P2093
J Schlessinger
O Silvennoinen
P2888
P304
P356
10.1038/366583A0
P407
P50
P577
1993-12-01T00:00:00Z
P5875
P6179
1046404612