Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.
about
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene clusterThe SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signalsInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayKinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral stateThe amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptorModulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode DependentThe crystal structure of human interferon beta at 2.2-A resolutionThe type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor proteinHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeCharacterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alphaCatalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinaseInterferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinaseTYK2 kinase activity is required for functional type I interferon responses in vivoA dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.Janus kinases: components of multiple signaling pathways.Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitisThe tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.The JAK/STAT pathway and Drosophila development.Jak2-Stat5 interactions analyzed in yeast.Regulation of the Jak2 tyrosine kinase by its pseudokinase domainThe pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.Jaks, STATs, Cytokines, and Sepsis.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Janus kinase 3: the controller and the controlledStructural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Ligand-independent interaction of the type I interferon receptor complex is necessary to observe its biological activity.Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions.Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling.The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.Inhibition of alpha interferon but not gamma interferon signal transduction by phorbol esters is mediated by a tyrosine phosphatase.JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism.JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
P2860
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P2860
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.
description
1995 nî lūn-bûn
@nan
1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Distinct domains of the protei ...... a and for signal transduction.
@ast
Distinct domains of the protei ...... a and for signal transduction.
@en
Distinct domains of the protei ...... a and for signal transduction.
@nl
type
label
Distinct domains of the protei ...... a and for signal transduction.
@ast
Distinct domains of the protei ...... a and for signal transduction.
@en
Distinct domains of the protei ...... a and for signal transduction.
@nl
prefLabel
Distinct domains of the protei ...... a and for signal transduction.
@ast
Distinct domains of the protei ...... a and for signal transduction.
@en
Distinct domains of the protei ...... a and for signal transduction.
@nl
P2093
P2860
P356
P1476
Distinct domains of the protei ...... ta and for signal transduction
@en
P2093
G Barbieri
K E Mogensen
L Velazquez
S Pellegrini
P2860
P304
P356
10.1074/JBC.270.7.3327
P407
P50
P577
1995-02-01T00:00:00Z