A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.
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Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperonesDouble negative (CD3+ 4- 8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetesThe BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survivalThe transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingMetabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ culturesCD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ cultureDevelopment of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathwayT cells in mice expressing a transgenic human TCR beta chain get positively selected but cannot be activated in the periphery by signaling through TCR.The GTPase Rho has a critical regulatory role in thymus development.The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.Role of interleukin-7 in T-cell development from hematopoietic stem cells.Receptor editing in lymphocyte development and central tolerance.Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cellsBruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cellsBcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.Two distinct pathways of positive selection for thymocytes.Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytesUnique features of the pre-T-cell receptor alpha-chain: not just a surrogate.Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cellsLaminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrinsDimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chainsDevelopmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.Nuclear factors that mediate intrathymic signals are developmentally regulated.Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, andDual T cell receptor beta chain expression on human T lymphocytes.The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunitLck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease.Domains of the TCR beta-chain required for early thymocyte development.An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) alpha chain: potential role in the regulation of cell surface pre-TCR expression levels.Constitutive endocytosis and degradation of the pre-T cell receptor.Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.The biological activity of natural and mutant pTalpha allelesDevelopmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancerRole of different T cell receptors in the development of pre-T cells.Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta tra
P2860
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P2860
A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
A novel disulfide-linked heter ...... hain and a 33 kd glycoprotein.
@en
type
label
A novel disulfide-linked heter ...... hain and a 33 kd glycoprotein.
@en
prefLabel
A novel disulfide-linked heter ...... hain and a 33 kd glycoprotein.
@en
P2093
P1433
P1476
A novel disulfide-linked heter ...... hain and a 33 kd glycoprotein.
@en
P2093
Groettrup M
Palacios R
Ungewiss K
von Boehmer H
P304
P356
10.1016/0092-8674(93)80070-U
P407
P577
1993-10-01T00:00:00Z