IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainNon-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptorAssociation of insulin receptor substrate 1 with simian virus 40 large T antigenDistinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domainsGrowth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid systemEpidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptorsIRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisStimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositolShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsT cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complexThe structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinaseLipid biology of breast cancerHistory of interleukin-4Engagement of Gab1 and Gab2 in erythropoietin signalingIdentification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent mannerTyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptorErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationThe type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient miceMonocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytesInteraction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activationThe Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cellsConsequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblastsThe Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulationInterferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinaseJanus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferonsThe role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesisA casein kinase I activity is constitutively associated with Nck.Role of IRS-1-GRB-2 complexes in insulin signaling.Differentiation and malignant transformation: two roads diverged in a wood.The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?IGF-I receptor signalling in transformation and differentiation.Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.
P2860
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P2860
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
@en
type
label
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
@en
prefLabel
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
@en
P2093
P356
P1433
P1476
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells.
@en
P2093
P304
P356
10.1126/SCIENCE.8372354
P407
P577
1993-09-01T00:00:00Z