The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
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Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transportAssociation of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulinThe exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes.Cross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytesThe sorbin homology domain: a motif for the targeting of proteins to lipid raftsLipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actinCrystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activationOxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytesChronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytesThe protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinaseChronic ethanol feeding impairs endothelin-1-stimulated glucose uptake via decreased G alpha 11 expression in rat adipocytesDecreased insulin-dependent glucose transport by chronic ethanol feeding is associated with dysregulation of the Cbl/TC10 pathway in rat adipocytesActivation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscleIdentification of the APS protein as a novel insulin receptor substrateLipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation.GLUT4--at the cross roads between membrane trafficking and signal transduction.Signaling pathways in insulin action: molecular targets of insulin resistanceInsulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension.The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocationA phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.Insulin signaling and the regulation of glucose transport.Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes.Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.Insulin signalling to the kidney in health and disease.Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.Glucose deprivation enhances targeting of GLUT1 to lipid rafts in 3T3-L1 adipocytes.Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.Reconstitution of insulin signaling pathways in rat 3Y1 cells lacking insulin receptor and insulin receptor substrate-1. Evidence that activation of Akt is insufficient for insulin-stimulated glycogen synthesis or glucose uptake in rat 3Y1 cells.Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance.Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes.Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum.Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin.GLUT4 vesicle dynamics in living 3T3 L1 adipocytes visualized with green-fluorescent proteinThe trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes.Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3.Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting.Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes.
P2860
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P2860
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@ast
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@en
type
label
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@ast
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@en
prefLabel
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@ast
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@en
P2093
P2860
P356
P1476
The inability of phosphatidyli ...... lin-stimulated glucose uptake.
@en
P2093
P2860
P304
10247-10251
P356
10.1073/PNAS.92.22.10247
P407
P577
1995-10-01T00:00:00Z