Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.
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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activationStructural and functional studies of the intracellular tyrosine kinase MATK gene and its translated productAssociation of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cellsIntroduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinasesTranslocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated plateletsPositive and negative regulation of T-cell activation through kinases and phosphatasesSH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCFOverexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreadingDifferential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitinationThe murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin networkThe crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loopA catalytically active Jak2 is required for the angiotensin II-dependent activation of FynSrc kinase activity is regulated by the SHP-1 protein-tyrosine phosphataseMolecular interaction between limb deformity proteins (formins) and Src family kinasesHrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatasesTargeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosisSerum response factor is essential for mesoderm formation during mouse embryogenesisRoles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functionsA multi-omics approach identifies key hubs associated with cell type-specific responses of airway epithelial cells to staphylococcal alpha-toxin.Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signalingAssociation of Csk to VE-cadherin and inhibition of cell proliferationThe Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocationA mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53The regulation of N-methyl-D-aspartate receptors by Src kinase.Src family kinases are required for integrin but not PDGFR signal transduction.State and role of SRC family kinases in replication of herpes simplex virus 1.C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain.Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.Wild-type and mutant forms of v-src differentially alter neuronal migration and differentiation in vivo.The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.Overexpression of C-terminal Src kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading.Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes.The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src.Regulation of the Src protein tyrosine kinase.SH3 domains specifically regulate kinase activity of expressed Src family proteins.Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.
P2860
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P2860
Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Disruption of the csk gene, en ...... d embryonic lethality in mice.
@en
type
label
Disruption of the csk gene, en ...... d embryonic lethality in mice.
@en
prefLabel
Disruption of the csk gene, en ...... d embryonic lethality in mice.
@en
P1433
P1476
Disruption of the csk gene, en ...... d embryonic lethality in mice.
@en
P2093
P304
P356
10.1016/0092-8674(93)90641-3
P407
P577
1993-06-01T00:00:00Z