The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
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Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndromeParallel evolution of KCNQ4 in echolocating batsCooperative activation of the T-type CaV3.2 channel: interaction between Domains II and III.Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome.KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) proteinDouble mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.Tryptophan scanning mutagenesis of the first transmembrane domain of the innexin Shaking-B(Lethal).Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits.Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Coupling of voltage-sensors to the channel pore: a comparative viewPerspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Identification of functionally critical residues in the channel domain of inositol trisphosphate receptorsIntra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State InactivationIon channel-transporter interactions.Aromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process.Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.Cytoplasmic domains and voltage-dependent potassium channel gating.Mechanism of electromechanical coupling in voltage-gated potassium channels.Being flexible: the voltage-controllable activation gate of kv channels.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Molecular Pathophysiology of Congenital Long QT Syndrome.An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.Conserved gating elements in TRPC4 and TRPC5 channels.Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation.Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed statePredicting the Functional Impact of KCNQ1 Variants of Unknown Significance.Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR.
P2860
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P2860
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The S4-S5 linker of KCNQ1 chan ...... gment controlling gate closure
@en
type
label
The S4-S5 linker of KCNQ1 chan ...... gment controlling gate closure
@en
prefLabel
The S4-S5 linker of KCNQ1 chan ...... gment controlling gate closure
@en
P2093
P2860
P356
P1476
The S4-S5 linker of KCNQ1 chan ...... gment controlling gate closure
@en
P2093
Adam L Raes
Alain J Labro
Evy Mayeur
Frank S Choveau
Inge R Boulet
Tine Bruyns
P2860
P304
P356
10.1074/JBC.M110.146977
P407
P577
2010-11-08T00:00:00Z