Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice.
about
Activated Met signalling in the developing mouse heart leads to cardiac diseaseEvolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandEngineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signalingDREADDs: novel tools for drug discovery and developmentOptogenetic and Chemogenetic Approaches for Studying Astrocytes and GliotransmittersEngineering GPCR signaling pathways with RASSLsThe lac operator-repressor system is functional in the mouseModifying ligand-induced and constitutive signaling of the human 5-HT4 receptorClozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptorsOsteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formationEndothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.Tetracycline inducible gene manipulation in serotonergic neurons.What can transgenic and gene-targeted mouse models teach us about salivary gland physiology?In vivo expression of a conditional TGF-beta1 transgene: no evidence for TGF-beta1 transgene expression in SM22alpha-tTA transgenic miceTransgenic mice: beyond the knockoutA new transgenic mouse line for tetracycline inducible transgene expression in mature melanocytes and the melanocyte stem cells using the Dopachrome tautomerase promoter.Remote control of neuronal signaling.Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptorProbing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansionConstitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.New tools to build synthetic hormonal pathways.Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathyConditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice.Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.DREADDs for Neuroscientists.Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse.Neoceptors: reengineering GPCRs to recognize tailored ligandsGenetic dissection of neural circuitsResolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer DrugsEngineered GPCRs as tools to modulate signal transduction.
P2860
Q21136030-9F4EFC77-DF82-48B0-A802-C4BDD391CF10Q24676976-70A30E6B-1071-401D-9F52-1977B3DE2223Q24797337-A24A2404-D146-4DC6-91E8-A639C23FE10BQ26995396-6B4DF5B0-DF70-4813-A799-5FA1C49C1BD9Q28079130-9DF3B8F7-2027-4FFB-828C-300CF18F240AQ28289158-9A53145D-FFD3-43F0-ADFD-20CAE96B9811Q28366874-D38A2088-CDF9-4386-BF57-62131B843B5DQ28472395-D0D55A2D-4D53-4F5C-B89F-FDFD54601EDDQ30370324-71462268-FBAC-4787-8A40-3D2AD92467FDQ30476292-6DADAD42-68B7-46C0-BA55-0DDA98A46D36Q30479148-2EF9FBE8-4EE0-4959-86C9-37C61B6D2214Q30480475-85B278EC-D522-451E-AC61-59A834F5D55CQ30481229-82D80304-E5F5-4BA0-AA57-9BC5B4D51167Q30483008-410701C6-63E6-4D40-A3CC-82D8BDE59403Q33292675-7C40FA7B-066F-49C0-819D-878280725E3AQ33735917-EBB104F5-A891-48A1-A80A-70BDCB47E429Q33896087-41630F17-C7CF-401F-9BB6-8EB0E3ECDEB7Q34302418-8400AB16-CFAE-46DE-A274-C03E0A4CB3B8Q34528951-EEA03C19-6A3C-4C79-82E1-0C2A87D8F3D7Q34557394-ACB34610-84BD-423A-BE9C-629058955DFCQ34599891-40E1C5AE-D3A1-4CC6-A76E-9D5AFB46B47FQ34634627-4E934031-6FED-489C-AF02-0EE6AF5E251CQ34858531-121C09CB-59A1-4042-8AB0-2F0CA9AEA6CDQ35031675-E48CCB39-81A9-4A82-AAB8-2ACB543B2C52Q35119322-A4944CB5-5640-430A-98C7-44F92F7B7F84Q35156288-8EE0371E-9E7F-4168-8C88-7022B8773237Q35157007-91D72582-8610-4617-A8BE-4EA93F14403EQ35579256-BE4D25EC-BE25-4677-A443-D8832745D4A6Q35690919-9620ED8B-A806-45B2-8B72-063C4F669668Q36022786-FCA10E0D-DE9E-46BE-87A4-BAE9C4D57F3DQ36311525-43F394D8-062B-4B70-947F-86B09526847FQ36316851-9C06547A-85CC-4DCE-B791-A2B13504C4A5Q36326357-BC1B3951-E3F5-4903-8371-AA46EF9E58BBQ36509788-C641A5A4-4801-4CCA-9DF7-5C75484244C5Q36595793-D2FAF476-4A1D-40CC-B889-E0655DC8F4F1Q36626396-4F4A3C22-B7D6-4B50-8981-E87B6682E3D0Q36728991-D694E5D4-1154-4256-9FBB-01D953856EC3Q37110384-57D0667C-4B25-4750-8847-4F297B71F3B1Q37235970-925E1C37-DBC4-40F5-94B7-06CF940320BCQ37346874-B77489FB-8514-4DAE-BA0F-5EC4D84C4D0C
P2860
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Conditional expression and sig ...... d receptor in transgenic mice.
@en
type
label
Conditional expression and sig ...... d receptor in transgenic mice.
@en
prefLabel
Conditional expression and sig ...... d receptor in transgenic mice.
@en
P2093
P356
P1433
P1476
Conditional expression and sig ...... d receptor in transgenic mice.
@en
P2093
Conklin BR
Degtyarev MY
Fishman GI
Hennighausen L
Redfern CH
P2888
P304
P356
10.1038/6165
P577
1999-02-01T00:00:00Z
P5875
P6179
1050167102