Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

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Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models.

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Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

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2015 nî lūn-bûn

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2015年論文

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Helper-dependent adenovirus ac ...... mates under immunosuppression.

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Helper-dependent adenovirus ac ...... mates under immunosuppression.

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Helper-dependent adenovirus ac ...... mates under immunosuppression.

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Helper-dependent adenovirus ac ...... imates under immunosuppression

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Progress and prospects: immune responses to viral vectors

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons.

Improved efficacy and reduced toxicity by ultrasound-guided intrahepatic injections of helper-dependent adenoviral vector in Gunn rats.

Adenoviral vector immunity: its implications and circumvention strategies.

Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates

AAV8-mediated gene therapy prevents induced biochemical attacks of acute intermittent porphyria and improves neuromotor function.

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates

Recommendations for the diagnosis and treatment of the acute porphyrias.

Sustained enzymatic correction by rAAV-mediated liver gene therapy protects against induced motor neuropathy in acute porphyria mice.

Current strategies and future directions for eluding adenoviral vector immunity

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gt.2015.64

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scholarly article

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10.1038/GT.2015.64

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Sandra Hervas-Stubbs

Uxua Mancheño

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2015-07-23T00:00:00Z

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immunosuppression

Adenoviridae

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

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P2860

P2860

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

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