about
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primatesConventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming.Identification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy.Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12.Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver.Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.
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Q33822191-7734DAA6-255F-485D-BA9A-29B72BCC7312Q33927128-FE1C7375-D2CB-4F09-BB34-D83D3063A514Q36782499-B0614D83-F956-4584-B155-3B13B345ACFDQ38775981-62B9FF55-31EF-425B-BECA-1BAD4251C3EEQ38926780-ED20536F-3F77-4BBB-8101-B6B27CCF2B48Q41627013-5BE9BB55-7536-4E9E-86D7-92E70AEFD241Q42223027-09FFFE9C-52FB-472A-99CC-DD3C87020716Q45863676-12BE9B2B-1933-4D1F-A2F1-1E210293D124Q45881397-ADA39CBC-4F87-49C5-80DE-98943747A379
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Uxua Mancheño
@en
Uxua Mancheño
@nl
type
label
Uxua Mancheño
@en
Uxua Mancheño
@nl
prefLabel
Uxua Mancheño
@en
Uxua Mancheño
@nl
P31
P496
0000-0003-1533-0371