Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells.
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Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptidesThe growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylasesBCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to PML oncogenic domainsEffects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.Nanotechnology applications in hematological malignancies (Review).A PMLRARalpha transgene initiates murine acute promyelocytic leukemiaCell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias.
P2860
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P2860
Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Promyelocytic leukemia-specifi ...... an erythroleukemia K562 cells.
@en
type
label
Promyelocytic leukemia-specifi ...... an erythroleukemia K562 cells.
@en
prefLabel
Promyelocytic leukemia-specifi ...... an erythroleukemia K562 cells.
@en
P2093
P1433
P1476
Promyelocytic leukemia-specifi ...... an erythroleukemia K562 cells.
@en
P2093
F Grignani
P G Pelicci
R Masciulli
P304
P407
P577
1995-01-01T00:00:00Z