Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs.
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Identification of direct protein targets of small moleculesAnthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctionsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateCysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probesProgrammed cell death in Leishmania: biochemical evidence and role in parasite infectivityDevelopment of calpain-specific inactivators by screening of positional scanning epoxide librariesSynthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase IToxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone PhenylRational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBThe Trypanosoma cruzi protease cruzain mediates immune evasionProteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Characteristics of the caspase-like catalytic domain of human paracaspase.Chemical approaches for functionally probing the proteome.Epoxysuccinyl peptide-derived affinity labels for cathepsin B.Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.Applications for chemical probes of proteolytic activity.RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.High-resolution functional proteomics by active-site peptide profilingNeuronal loss and brain atrophy in mice lacking cathepsins B and LChemical proteomics: terra incognita for novel drug target profiling.Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate.Imaging proteolysis by living human breast cancer cells.Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasionStrategies for facilitated forward chemical genetics.Invariant chain controls the activity of extracellular cathepsin L.Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasitesHaemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisininsDrug discovery and development for neglected parasitic diseases.A parasite cysteine protease is key to host protein degradation and iron acquisition.Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases.VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.Activity-based probes as a tool for functional proteomic analysis of proteases.Cysteine tagging for MS-based proteomics.Activity-based probes for the study of proteases: recent advances and developments.Active-site peptide "fingerprinting" of glycosidases in complex mixtures by mass spectrometry. Discovery of a novel retaining beta-1,4-glycanase in Cellulomonas fimi.
P2860
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P2860
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Selective targeting of lysosom ...... ectrophilic substrate analogs.
@en
type
label
Selective targeting of lysosom ...... ectrophilic substrate analogs.
@en
prefLabel
Selective targeting of lysosom ...... ectrophilic substrate analogs.
@en
P2093
P1476
Selective targeting of lysosom ...... ectrophilic substrate analogs.
@en
P2093
Bellingard-Dubouchaud V
Greenbaum D
Verhelst S
P356
10.1016/S1074-5521(00)00061-2
P577
2000-01-01T00:00:00Z