Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis.
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Hereditary chronic pancreatitisHuman mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitorsHuman anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseasesInactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humansUncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutationsHereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanismMutations of human cationic trypsinogen (PRSS1) and chronic pancreatitisBiochemical models of hereditary pancreatitisHereditary pancreatitis: current perspectivesStructural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsinThe P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activityPresence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitorsChymotrypsin C mutations in chronic pancreatitis.Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitisNovel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitisA new polymorphism for the RI22H mutation in hereditary pancreatitisMesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as SubstratesA degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitisHuman mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chainsThe amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell deathChymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.Intragenic duplication: a novel mutational mechanism in hereditary pancreatitisCold adaptation, ca2+ dependency and autolytic stability are related features in a highly active cold-adapted trypsin resistant to autoproteolysis engineered for biotechnological applications.Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.Chronic pancreatitis and cystic fibrosis.Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.Protein surface charge of trypsinogen changes its activation pattern.The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin CGenetics of pancreatitis.Hereditary Pancreatitis Associated With the N29T Mutation of the PRSS1 Gene in a Brazilian Family: A Case-Control Study.Hereditary pancreatitis for the endoscopistPathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitisTighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.Biochemical and structural insights into mesotrypsin: an unusual human trypsin.The guinea pig pancreas secretes a single trypsinogen isoform, which is defective in autoactivation.Hereditary pancreatitis of 3 Chinese children: Case report and literature review.Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl
P2860
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P2860
Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Human cationic trypsinogen. Ro ...... ns in hereditary pancreatitis.
@en
type
label
Human cationic trypsinogen. Ro ...... ns in hereditary pancreatitis.
@en
prefLabel
Human cationic trypsinogen. Ro ...... ns in hereditary pancreatitis.
@en
P2860
P356
P1476
Human cationic trypsinogen. Ro ...... ns in hereditary pancreatitis.
@en
P2093
Sahin-Tóth M
P2860
P304
22750-22755
P356
10.1074/JBC.M002943200
P407
P577
2000-07-01T00:00:00Z