Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
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Novel bioinformatic developments for exome sequencingMouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?Intracellular Molecular Differences in Aldosterone- Compared to Cortisol-Secreting Adrenal Cortical AdenomasDNAJB1-PRKACA is specific for fibrolamellar carcinoma.Insights from exome sequencing for endocrine disordersThe roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.Uncovering Aberrant Mutant PKA Function with Flow Cytometric FRETProtein kinase A catalytic subunit isoform PRKACA; History, function and physiologyGenomic analysis of fibrolamellar hepatocellular carcinoma.Structural insights into mis-regulation of protein kinase A in human tumors.Pediatric adrenocortical tumors: what they can tell us on adrenal development and comparison with adult adrenal tumors.Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations.Two-pore domain potassium channels in the adrenal cortex.PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRsDevelopment of adrenal cortex zonation.Protein kinase A defects and cortisol-producing adrenal tumorsSteroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma.Regulation of the adrenocortical stem cell niche: implications for diseaseThe pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.Activating mutations in CTNNB1 in aldosterone producing adenomas.Molecular Heterogeneity in Aldosterone-Producing AdenomasAdrenal Cushing's syndrome in pregnancy: Clinical and molecular characterisation of a case.Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy.Clinicopathological correlates of adrenal Cushing's syndrome.Cushing's syndrome: from physiological principles to diagnosis and clinical care.Genetics of adrenal diseases in 2014: Genetics improves understanding of adrenocortical tumours.Cancer genomics: why rare is valuable.Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors.Importance of gene dosage in controlling dendritic arbor formation during development.5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.A genetic and molecular update on adrenocortical causes of Cushing syndrome.Genetics of adrenocortical tumours.Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival.Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016).PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia.Genetic screening in arterial hypertension.Genetics of Adrenocortical Development and Tumors.Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia
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P2860
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
@en
type
label
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
@en
prefLabel
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
@en
P2093
P2860
P50
P356
P1433
P1476
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome
@en
P2093
Aiko Sato-Otsubo
Haruki Kume
Hiroko Tanaka
Hiromichi Suzuki
Keisuke Kataoka
Kenichi Chiba
Kosuke Aoki
Masashi Fukayama
Masashi Sanada
P2860
P304
P356
10.1126/SCIENCE.1252328
P407
P577
2014-05-01T00:00:00Z