Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice - Wikidata - wikimedia - TriplyDB

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

http://www.wikidata.org/entity/Q41807812

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Mutational processes molding the genomes of 21 breast cancers Separate roles of structured and unstructured regions of Y-family DNA polymerases Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.A role for PCNA ubiquitination in immunoglobulin hypermutation.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Cross-link structure affects replication-independent DNA interstrand cross-link repair in mammalian cells Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase Refining the Neuberger model: Uracil processing by activated B cells.AID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Maternal aldehyde elimination during pregnancy preserves the fetal genome Translesion DNA polymerases Involvement of Rad18 in somatic hypermutation DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.DNA polymerase zeta (pol zeta) in higher eukaryotes.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.FF483-484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites.Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions What a difference a decade makes: insights into translesion DNA synthesis.HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase Does DNA repair occur during somatic hypermutation?A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair.A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ PCNA modifications for regulation of post-replication repair pathways DNA repair in antibody somatic hypermutation.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

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P2860

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

http://www.wikidata.org/entity/Q41807812

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Strand-biased defect in C/G tr ...... n genes in Rev1-deficient mice

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type

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Strand-biased defect in C/G tr ...... n genes in Rev1-deficient mice

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Strand-biased defect in C/G tr ...... n genes in Rev1-deficient mice

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P1433

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P1433

Journal of Experimental Medicine

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Strand-biased defect in C/G tr ...... n genes in Rev1-deficient mice

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P2093

Anastasia Tsaalbi-Shtylik

http://www.w3.org/2001/XMLSchema#string

Heinz Jacobs

http://www.w3.org/2001/XMLSchema#string

Jacob G Jansen

http://www.w3.org/2001/XMLSchema#string

Niels de Wind

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Paul van den Berk

http://www.w3.org/2001/XMLSchema#string

Petra Langerak

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P2860

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

Immunity through DNA deamination

Interaction of hREV1 with three human Y-family DNA polymerases

Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage

Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

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319-323

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10.1084/JEM.20052227

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2

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203

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7299767

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16476771

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2118202

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