A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification - Wikidata - wikimedia - TriplyDB

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

http://www.wikidata.org/entity/Q36229591

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hMMS2 serves a redundant role in human PCNA polyubiquitination CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites Predisposition to cancer caused by genetic and functional defects of mammalian Atad5 Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation Simultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathways The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination ATAD5 deficiency decreases B cell division and Igh recombination The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Histone H2A and H2B are monoubiquitinated at AID-targeted loci.Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Hypomorphic PCNA mutation underlies a human DNA repair disorder.Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.Refining the Neuberger model: Uracil processing by activated B cells.PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.AID and somatic hypermutation.Msh6 protects mature B cells from lymphoma by preserving genomic stability.Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.Mismatch-mediated error prone repair at the immunoglobulin genes.DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase Does DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination Y-family DNA polymerases and their role in tolerance of cellular DNA damage.Non-conservative homologous recombination in human B lymphocytes is promoted by activation-induced cytidine deaminase and transcription.Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.PrimPol prevents APOBEC/AID family mediated DNA mutagenesis High-fidelity correction of genomic uracil by human mismatch repair activities.E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.

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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

http://www.wikidata.org/entity/Q36229591

description

2007 nî lūn-bûn

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2007年の論文

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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A/T mutagenesis in hypermutate ...... pends on PCNAK164 modification

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Anders O H Nygren

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Heinz Jacobs

http://www.w3.org/2001/XMLSchema#string

Paul C M van den Berk

http://www.w3.org/2001/XMLSchema#string

Peter H L Krijger

http://www.w3.org/2001/XMLSchema#string

Petra Langerak

http://www.w3.org/2001/XMLSchema#string

P2860

Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.

The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.

The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Immunity through DNA deamination

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

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1989-1998

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10.1084/JEM.20070902

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204

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17664295

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2118671

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