Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
about
Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signallingRaf-interactome in tuning the complexity and diversity of Raf function.The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathwayHECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancerChange or die: targeting adaptive signaling to kinase inhibition in cancer cells.Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteinsInduction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant CellsA SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathyTowards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response.Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.Targeting oncogenic BRAF in human cancer.Spry regulation of FGF signalingDiscrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.SPRY2 is phosphorylated by phosphorylated MNK1SPRY2 is serine phosphorylated in response to MAPK activationB-RAF dissociates from S111/S120 p-SPRY2Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells.
P2860
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P2860
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
@en
type
label
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
@en
prefLabel
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
@en
P2093
P2860
P1433
P1476
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
@en
P2093
June Munro
Nicolas A Morrice
Stephan M Feller
Suzanne C Brady
P2860
P304
P356
10.1158/0008-5472.CAN-08-4447
P407
P577
2009-08-18T00:00:00Z