Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
about
The Prodrug Approach: A Successful Tool for Improving Drug SolubilityTricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agentsA novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteriaChallenges of antibacterial discoveryHigh in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea.A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening.Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.Bacterial DNA replication enzymes as targets for antibacterial drug discovery.Multitarget ligands in antibacterial research: progress and opportunities.Novel targets for antibiotics in Staphylococcus aureus.Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteriaEvaluation of WO2012177707 and WO2012097269: Vertex's phosphate prodrugs of gyrase and topoisomerase antibacterial agents.
P2860
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P2860
Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
description
2006 nî lūn-bûn
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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2006年论文
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2006年论文
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name
Dual targeting of GyrB and Par ...... ass of antibacterial compounds
@en
type
label
Dual targeting of GyrB and Par ...... ass of antibacterial compounds
@en
prefLabel
Dual targeting of GyrB and Par ...... ass of antibacterial compounds
@en
P2093
P2860
P356
P1476
Dual targeting of GyrB and Par ...... ass of antibacterial compounds
@en
P2093
Anne-Laure Grillot
Christian H Gross
Dean Stamos
Douglas J Bartels
Eric R Olson
Jonathan D Parsons
Nagraj Mani
Paul S Charifson
Steve Mullin
Trudy H Grossman
P2860
P304
P356
10.1128/AAC.00596-06
P407
P577
2006-11-20T00:00:00Z