Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.
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Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparumExpression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor ClassesDrug resistance genomics of the antimalarial drug artemisininThe interplay between drug resistance and fitness in malaria parasitesIn vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genesMolecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin-based combination therapy.Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria.Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites.Emerging artemisinin resistance in the border areas of Thailand.Spontaneous mutations in the Plasmodium falciparum sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies.Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies.Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion.Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparumExtracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum.Characterization of the Plasmodium falciparum sarcoplasmic/endoplasmic reticulum Ca2+-ATPase gene in samples from Equatorial Guinea before implementation of artemisinin-based combination therapy.Molecular assessment of atpase6 mutations associated with artemisinin resistance among unexposed and exposed Plasmodium falciparum clinical isolates to artemisinin-based combination therapy.Melatonin signaling and its modulation of PfNF-YB transcription factor expression in Plasmodium falciparum.Antimalarial drugs: modes of action and mechanisms of parasite resistance.Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites.Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²⁺-ATPase PfATP6.Susceptibility of human Plasmodium knowlesi infections to anti-malarials.Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites.Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.The structurally related auxin and melatonin tryptophan-derivatives and their roles in Arabidopsis thaliana and in the human malaria parasite Plasmodium falciparum.A general approach to the basiliolide/transtaganolide natural products: total syntheses of basiliolide B, epi-8-basiliolide B, transtaganolide C, and transtaganolide D.
P2860
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P2860
Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Investigations into the role o ...... misinin action and resistance.
@en
type
label
Investigations into the role o ...... misinin action and resistance.
@en
prefLabel
Investigations into the role o ...... misinin action and resistance.
@en
P2860
P50
P356
P1476
Investigations into the role o ...... misinin action and resistance.
@en
P2093
Anne-Catrin Uhlemann
Daniel Scanfeld
P2860
P304
P356
10.1128/AAC.00121-10
P407
P577
2010-06-21T00:00:00Z