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The transcription factor p53: not a repressor, solely an activatorRole of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175Hβ1 Integrins as Therapeutic Targets to Disrupt Hallmarks of CancerWild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cellsMammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells.Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell linesContribution of p53 to metastasis.Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisThe prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancerFAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.Napsin A as a marker of clear cell ovarian carcinoma.Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signalFocal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival.Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and p53-mutant colorectal cancer cells.Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion.A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cellsCell survival signaling in neuroblastoma.Negative control of CSL gene transcription by stress/DNA damage response and p53.A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.Focal adhesion kinase versus p53: apoptosis or survival?Neuroblastoma and MYCNFAK overexpression and p53 mutations are highly correlated in human breast cancer.Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion.ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.Focal adhesion kinase and p53 signal transduction pathways in cancer.Focal adhesion kinase as a cancer therapy target.FAK and p53 protein interactions.FAK and Nanog cross talk with p53 in cancer stem cells.Targeting FAK in human cancer: from finding to first clinical trials.Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review.NANOG: a promising target for digestive malignant tumorsXEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway.Loss of P53 facilitates invasion and metastasis of prostate cancer cells.Delayed caspase-8 activation and enhanced integrin β1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
p53 regulates FAK expression in human tumor cells
@en
type
label
p53 regulates FAK expression in human tumor cells
@en
prefLabel
p53 regulates FAK expression in human tumor cells
@en
P2093
P2860
P356
P1476
p53 regulates FAK expression in human tumor cells
@en
P2093
Margaret R Wallace
Nicole A Massoll
Richard Finch
Vita M Golubovskaya
William G Cance
P2860
P304
P356
10.1002/MC.20395
P577
2008-05-01T00:00:00Z