Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma - Wikidata - wikimedia - TriplyDB

Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

http://www.wikidata.org/entity/Q41888346

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Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling Raf family kinases: old dogs have learned new tricks Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF To BRAF or not to BRAF: is that even a question anymore?Modern brain tumor imaging MAPK pathway activation in pilocytic astrocytoma The molecular biology of WHO grade I astrocytomas Will kinase inhibitors make it as glioblastoma drugs?Pathological and molecular advances in pediatric low-grade astrocytoma Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice Raf kinases in cancer-roles and therapeutic opportunities Pilocytic astrocytoma: a disease with evolving molecular heterogeneity Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas BRAF V600E-mutated diffuse glioma in an adult patient: a case report and review.A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma.Gliomas in adults.Pediatric low-grade gliomas: how modern biology reshapes the clinical field.BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.Activation of the Hedgehog pathway in pilocytic astrocytomas.PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update.Biology, genetics and imaging of glial cell tumours Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program.The landscape of kinase fusions in cancer A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702)MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131B-BRAF fusions in pediatric low-grade Gliomas.The BRAF kinase domain promotes the development of gliomas in vivo.Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma.KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas.Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape.A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study†Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma.Emerging insights into the molecular and cellular basis of glioblastoma.

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Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

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D M Pearson

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D T W Jones

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K Ichimura

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L Liu

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S Kocialkowski

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P2860

Back to the roots: the remarkable RAF oncogene story

The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

Tumor microenvironment and neurofibromatosis type I: connecting the GAPs

The 2007 WHO classification of tumours of the central nervous system

Mutations of the BRAF gene in human cancer

The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

Structure of the activated c-raf-1 gene from human stomach cancer

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

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