Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis.
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Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosisComplexins: small but capableCis- and trans-membrane interactions of synaptotagmin-1Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cellsRat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusionSynaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusionA DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosisSynaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strengthInteraction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy.In vitro membrane reconstitution of the T-cell receptor proximal signaling network.Docking, not fusion, as the rate-limiting step in a SNARE-driven vesicle fusion assaySynaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions.Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition.Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion.Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo.Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.Mechanism and function of synaptotagmin-mediated membrane apposition.Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor.Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.Different states of synaptotagmin regulate evoked versus spontaneous release.Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy.Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.The Mechanisms and Functions of Synaptic Facilitation.Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.Arabidopsis synaptotagmin SYT1, a type I signal-anchor protein, requires tandem C2 domains for delivery to the plasma membrane.Mechanism of neurotransmitter release coming into focus
P2860
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P2860
Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Synaptotagmin C2B domain regul ...... scanning alanine mutagenesis.
@en
type
label
Synaptotagmin C2B domain regul ...... scanning alanine mutagenesis.
@en
prefLabel
Synaptotagmin C2B domain regul ...... scanning alanine mutagenesis.
@en
P2093
P2860
P356
P1476
Synaptotagmin C2B domain regul ...... scanning alanine mutagenesis.
@en
P2093
Edwin R Chapman
F Mark Dunning
Jon D Gaffaney
P2860
P304
31763-31775
P356
10.1074/JBC.M803355200
P407
P577
2008-09-10T00:00:00Z