The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue - Wikidata - wikimedia - TriplyDB

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

http://www.wikidata.org/entity/Q41912342

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Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease The FGF21-adiponectin axis in controlling energy and vascular homeostasis Fibroblast Growth Factor Signaling in Metabolic Regulation Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD Inventing new medicines: The FGF21 story Stressed Liver and Muscle Call on Adipocytes with FGF21 Transcriptional regulation of fibroblast growth factor 21 expression Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21 Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders.Protein-dependent regulation of feeding and metabolism FGF21 requires βklotho to act in vivo Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues.FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.The Fibroblast Growth Factor signaling pathway Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta).Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control.Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue.Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex.Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss.Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity.FGF21 and the late adaptive response to starvation in humans.Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats.Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease

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P2860

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

http://www.wikidata.org/entity/Q41912342

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2012 nî lūn-bûn

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2012年论文

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name

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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prefLabel

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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J.MOLMET.2012.08.007

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Molecular Metabolism

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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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Alexei Kharitonenkov

http://www.w3.org/2001/XMLSchema#string

Andrew C Adams

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Chaofeng Yang

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Christine C Cheng

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Ruth E Gimeno

http://www.w3.org/2001/XMLSchema#string

Tamer Coskun

http://www.w3.org/2001/XMLSchema#string

Yongde Luo

http://www.w3.org/2001/XMLSchema#string

P2860

FGF-21 as a novel metabolic regulator.

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

Fundamentals of FGF19 & FGF21 action in vitro and in vivo

FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

Fibroblast growth factor 21 corrects obesity in mice.

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

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31-37

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10.1016/J.MOLMET.2012.08.007

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