The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
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Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and DiseaseThe FGF21-adiponectin axis in controlling energy and vascular homeostasisFibroblast Growth Factor Signaling in Metabolic RegulationResearch Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLDInventing new medicines: The FGF21 storyStressed Liver and Muscle Call on Adipocytes with FGF21Transcriptional regulation of fibroblast growth factor 21 expressionDownstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders.Protein-dependent regulation of feeding and metabolismFGF21 requires βklotho to act in vivoRational design of a fibroblast growth factor 21-based clinical candidate, LY2405319Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in MiceRoux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male ratsMetabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues.FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissueFGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and DiseasesDeficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.The Fibroblast Growth Factor signaling pathwayActivation of Liver FGF21 in hepatocarcinogenesis and during hepatic stressTissue-specific actions of the metabolic hormones FGF15/19 and FGF21.LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic MonkeysIncreased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta).Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control.Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue.Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient dietRegulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytesPlasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformationSustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex.Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient dietsIgfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss.Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity.FGF21 and the late adaptive response to starvation in humans.Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats.Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease
P2860
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P2860
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
@en
type
label
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
@en
prefLabel
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
@en
P2093
P2860
P1433
P1476
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
@en
P2093
Alexei Kharitonenkov
Andrew C Adams
Chaofeng Yang
Christine C Cheng
Ruth E Gimeno
Tamer Coskun
Yongde Luo
P2860
P356
10.1016/J.MOLMET.2012.08.007
P577
2012-08-28T00:00:00Z