Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
about
Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug actionAntimalarial drug discovery: efficacy models for compound screening.Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice.Current knowledge and challenges of antimalarial drugs for treatment and prevention in pregnancy.Novel antimalarial drug targets: hope for new antimalarial drugs.New approaches in antimalarial drug discovery and development: a review.Chloroquine-containing compounds: a patent review (2010 - 2014).Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines.4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.4-aminoquinoline-triazine-based hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum.Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents.Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies.Synthesis of quinolines via copper-catalyzed domino reactions of enaminones.Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activityTopological Features in Profiling the Antimalarial Activity Landscape of Anilinoquinolines: A Multipronged QSAR Study
P2860
Q33202744-487F2987-6A28-42D7-AB50-D0CB9C2D06D3Q33635667-7B577D3F-DBD2-40EE-9FC6-2F2BE45228D5Q34694853-2FFCDAE7-2C4B-4D35-B04E-8C137C3DCA48Q35790381-8473B476-F9CE-4266-B8EE-D4C3E7DE2FD0Q36086442-0A65A44F-8128-4D04-B11C-A791914FE791Q37358401-B86B6F36-7505-4316-870C-CA3474C16D8EQ37564489-AB04D7CA-C671-45FD-A7E5-89348E1267B5Q37735182-E383D06B-6BD3-4BDF-B33E-0973797D6EC2Q37960187-401D9EBC-373E-4912-84E0-9A8BEE9F6E23Q38059380-D9386968-5D09-4521-9E69-6552BC3DE3B6Q38503439-6CB50FF8-43FC-4E38-BF98-0630B0E67A55Q38750426-8F296A0D-31AD-47B6-A10D-6EF531BF9949Q41772843-C10E18E6-07FB-4196-A55A-35A723AAFC79Q41775488-7C7BD4C2-DAA1-481F-A674-33332AE765D7Q41917145-3E8DB0AA-F4BA-49C8-AF39-10E1124F5912Q41927067-931FD121-F887-4496-87D7-1BC98CB282BEQ41928430-028A7FDF-AFA3-4D15-A746-5B2802422F25Q41941261-A9FDF966-60A6-4A2F-A524-8AEC19DF2907Q48005091-865E729E-086F-4790-8E1A-33C0C697133AQ53092908-66FDD042-91BD-45DB-B81E-55488DEBF411Q58568501-F086D5AC-7050-4699-9860-DE80A31C9DC6Q59008919-8C36340D-E5B4-47A9-B5FD-329BB5542F68
P2860
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Novel short chain chloroquine ...... tant K1 Plasmodium falciparum.
@en
type
label
Novel short chain chloroquine ...... tant K1 Plasmodium falciparum.
@en
prefLabel
Novel short chain chloroquine ...... tant K1 Plasmodium falciparum.
@en
P2093
P356
P1476
Novel short chain chloroquine ...... tant K1 Plasmodium falciparum.
@en
P2093
B Kevin Park
Kaylene J Raynes
Patrick G Bray
Paul A Stocks
Paul M O'Neill
Stephen A Ward
P304
P356
10.1021/JM0108707
P407
P577
2002-11-01T00:00:00Z