Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization
about
Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536Strategies to Inhibit Myc and Their Clinical ApplicabilityStructure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc.A quantitative, surface plasmon resonance-based approach to evaluating DNA binding by the c-Myc oncoprotein and its disruption by small molecule inhibitors.
P2860
Q30278518-7C5040DF-46EB-4EAC-ACAF-296846F04439Q35570730-D841A5BB-B824-4085-9E62-5337A166574DQ35601876-295BAA3C-FB6A-45F1-B571-C3E86098AAC6Q35697342-5C26D0BF-065C-4908-BC4A-D7A54886E245Q36303678-FA9930C1-03F2-4FF2-A427-66144E23FFFBQ36638977-34EBF9A6-3900-4781-AB9A-62E85447EA38Q41880916-5AA94764-4DAB-40D7-BACB-1B810DB6BC1A
P2860
Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Discovery of methyl 4'-methyl- ...... itor of c-Myc-max dimerization
@en
type
label
Discovery of methyl 4'-methyl- ...... itor of c-Myc-max dimerization
@en
prefLabel
Discovery of methyl 4'-methyl- ...... itor of c-Myc-max dimerization
@en
P2093
P2860
P356
P1433
P1476
Discovery of methyl 4'-methyl- ...... itor of c-Myc-max dimerization
@en
P2093
Edward V Prochownik
Huabo Wang
Jay Chauhan
Jeremy L Yap
Philip E Sabato
Steven Fletcher
P2860
P304
P356
10.1002/CMDC.201402189
P577
2014-06-27T00:00:00Z