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Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

http://www.wikidata.org/entity/Q41921136

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Redox mechanisms in age-related lung fibrosis Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts Role of redoximiRs in fibrogenesis Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis The balance of powers: Redox regulation of fibrogenic pathways in kidney injury Glutathione: new roles in redox signaling for an old antioxidant Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis Mitochondria in lung disease Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGF-β pathway in precancerous Oral Submucous Fibrosis.Grape seed proanthocyanidins prevent irradiation-induced differentiation of human lung fibroblasts by ameliorating mitochondrial dysfunction.The metabolic profile of a rat model of chronic kidney disease.The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway.Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop.Hypoxia enhances differentiation of mouse embryonic stem cells into definitive endoderm and distal lung cells.Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure.Suppressors of superoxide production from mitochondrial complex III Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation.Specific Mechanisms Underlying Right Heart Failure: The Missing Upregulation of Superoxide Dismutase-2 and Its Decisive Role in Antioxidative Defense.myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience: A NEW MECHANISM RELEVANT TO THE PATHOGENESIS OF DIABETIC NEPHROPATHY Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.High leukocyte mtDNA content contributes to poor prognosis through ROS-mediated immunosuppression in hepatocellular carcinoma patients Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics.Mechanistic links between aging and lung fibrosis.Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition.Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury Potential therapeutic targets for hypoxia-induced pulmonary artery hypertension.Stromal Modulators of TGF-β in Cancer.Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III.SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.

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Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

http://www.wikidata.org/entity/Q41921136

description

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2012年论文

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name

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

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type

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Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

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prefLabel

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

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JBC.M112.431973

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Journal of Biological Chemistry

P1476

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

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P2093

Aaron Zirk

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Elena A Monclus

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G R Scott Budinger

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Gokhan M Mutlu

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James Eisenbart

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Lauren Synenki

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Manu Jain

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Navdeep S Chandel

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Stephanie Rivera

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P2860

Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis.

Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling.

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts.

NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.

Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.

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10.1074/JBC.M112.431973

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2

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288

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Carol Feghali-Bostwick

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2012-11-30T00:00:00Z

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23204521

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3543026

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