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Integrated allosteric model of voltage gating of HCN channels.

Integrated allosteric model of voltage gating of HCN channels.

http://www.wikidata.org/entity/Q41949012

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Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels Identification of the molecular site of ivabradine binding to HCN4 channels Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster.I h and HCN channels in murine spiral ganglion neurons: tonotopic variation, local heterogeneity, and kinetic model.Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.Probability fluxes and transition paths in a Markovian model describing complex subunit cooperativity in HCN2 channels Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis.Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.HCN4-like immunoreactivity in rat retinal ganglion cells Cocaine sensitization inhibits the hyperpolarization-activated cation current Ih and reduces cell size in dopamine neurons of the ventral tegmental area Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.The contribution of RCK domains to human BK channel allosteric activation Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.Kinetic relationship between the voltage sensor and the activation gate in spHCN channels A novel mechanism of cone photoreceptor adaptation.Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides.Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gating K channel subconductance levels result from heteromeric pore conformations.Free-energy relationships in ion channels activated by voltage and ligand.Electrophysiology and pacemaker function of the developing sinoatrial node.Angiotensin II-Superoxide Signaling and Arterial Baroreceptor Function in Type-1 Diabetes Mellitus Modulation of HCN channels in lateral septum by nicotine.Engineering a biological pacemaker: in vivo, in vitro and in silico models Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned?Modeling ion channels: past, present, and future Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node.Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.

P2860

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P2860

Integrated allosteric model of voltage gating of HCN channels.

http://www.wikidata.org/entity/Q41949012

description

2001 nî lūn-bûn

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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2001年论文

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2001年论文

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name

Integrated allosteric model of voltage gating of HCN channels.

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Integrated allosteric model of voltage gating of HCN channels.

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Integrated allosteric model of voltage gating of HCN channels.

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P1433

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The Journal of General Physiology

P1476

Integrated allosteric model of voltage gating of HCN channels.

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A Bucchi

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A Moroni

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M Baruscotti

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P2860

Two pacemaker channels from human heart with profoundly different activation kinetics

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

The human gene coding for HCN2, a pacemaker channel of the heart

Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node.

A family of hyperpolarization-activated mammalian cation channels.

Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for calcium channel activation and dihydropyridine agonist action

An allosteric model of the molecular interactions of excitation-contraction coupling in skeletal muscle

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519-532

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2232403

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