Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs.

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Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

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Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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Probabilistic Approach to Gene ...... coring Function for CNS Drugs.

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Item

label

Probabilistic Approach to Gene ...... coring Function for CNS Drugs.

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Probabilistic Approach to Gene ...... coring Function for CNS Drugs.

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P1476

Probabilistic Approach to Gene ...... coring Function for CNS Drugs.

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P2093

Hakan Gunaydin

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity.

Drug-like property concepts in pharmaceutical design.

Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling.

CNS drug design: balancing physicochemical properties for optimal brain exposure.

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.

Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

De novo prediction of p-glycoprotein-mediated efflux liability for druglike compounds.

Quantifying the chemical beauty of drugs.

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

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89-93

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scholarly article

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10.1021/ACSMEDCHEMLETT.5B00390

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2015-12-02T00:00:00Z

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26819672

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4716604

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Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs.

about

P2860

P2860

Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

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P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932