Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke - Wikidata - wikimedia - TriplyDB

Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke

Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke

http://www.wikidata.org/entity/Q42023698

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Cell based therapies for ischemic stroke: from basic science to bedside A quantitative method for the specific assessment of caspase-6 activity in cell culture Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia.Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.Intranasal delivery of cell-penetrating anti-NF-κB peptides (Tat-NBD) alleviates infection-sensitized hypoxic-ischemic brain injury Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats Expression and activation of caspase-6 in human fetal and adult tissues Caspases: therapeutic targets in neurologic disease.Intranasal Delivery of Granulocyte Colony-Stimulating Factor Enhances Its Neuroprotective Effects Against Ischemic Brain Injury in Rats.Sox11 Reduces Caspase-6 Cleavage and Activity.Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus.Neuronal caspase 2 activity and function requires RAIDD, but not PIDD Caspase-9 mediates photoreceptor death after blunt ocular trauma Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke.Does Caspase-6 Have a Role in Perinatal Brain Injury?Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant.Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment.Molecular mechanisms of neonatal brain injury.Caspase inhibitors: prospective therapies for stroke.Caspase-6 as a novel early target in the treatment of Alzheimer's disease.The back and forth of axonal injury and repair after stroke.Apoptosis Following Cortical Spreading Depression in Juvenile Rats.Mechanisms of Axonal Damage and Repair after Central Nervous System Injury.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.Palmitoylation of caspase-6 by HIP14 regulates its activation.Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.GM1485, a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke.Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.Non-apoptotic Caspase regulation of stem cell properties.Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.Physiological functions of non-apoptotic caspase activity in the nervous system.14,15-EET Suppresses Neuronal Apoptosis in Ischemia-Reperfusion Through the Mitochondrial Pathway.Stem cell treatment after cerebral ischemia regulates the gene expression of apoptotic molecules.Learning on the Fly: The Interplay between Caspases and Cancer.

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Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke

http://www.wikidata.org/entity/Q42023698

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name

Intranasal delivery of caspase ...... ological function after stroke

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Intranasal delivery of caspase ...... ological function after stroke

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type

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Intranasal delivery of caspase ...... ological function after stroke

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Intranasal delivery of caspase ...... ological function after stroke

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Intranasal delivery of caspase ...... ological function after stroke

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Intranasal delivery of caspase ...... ological function after stroke

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JNEUROSCI.0698-11.2011

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Journal of Neuroscience

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Intranasal delivery of caspase ...... ological function after stroke

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Andrew F Ducruet

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Brad E Zacharia

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Carol M Troy

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Esther Serrano-Saiz

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Greg Cohen

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Guy S Salvesen

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Jennifer Velloza

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Nsikan Akpan

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Scott J Snipas

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Sergeyi A Sosunov

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P2860

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.

Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation

Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke.

Cleaved caspase-3 expression after experimental stroke exhibits different phenotypes and is predominantly non-apoptotic.

Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.

Human caspases: activation, specificity, and regulation

Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

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