Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria. - Wikidata - wikimedia - TriplyDB

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

http://www.wikidata.org/entity/Q42039730

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Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice Crystal structures of Entamoeba histolytica lysyl-tRNA synthetase reveal conformational changes upon lysine binding and a specific helix bundle domain Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.Mitochondrial dysfunction and intracellular calcium dysregulation in ALS Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer.ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities.Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis.Mitochondria: a therapeutic target in neurodegeneration Mitochondrial dysfunction in familial amyotrophic lateral sclerosis.Misfolded SOD1 and ALS: zeroing in on mitochondria.Is amyotrophic lateral sclerosis a mitochondrial channelopathy?The role of tRNA synthetases in neurological and neuromuscular disorders.

P2860

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P2860

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

http://www.wikidata.org/entity/Q42039730

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@en

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@nl

type

label

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@en

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@nl

prefLabel

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@en

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@nl

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P1433

Journal of Biological Chemistry

P1476

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.

@en

P2093

Catherine Kunst

http://www.w3.org/2001/XMLSchema#string

Giovanni Manfredi

http://www.w3.org/2001/XMLSchema#string

Hibiki Kawamata

http://www.w3.org/2001/XMLSchema#string

Jordi Magrané

http://www.w3.org/2001/XMLSchema#string

Michael P King

http://www.w3.org/2001/XMLSchema#string

P2860

The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript

Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V.

A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae.

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

Translation and transcription: the dual functionality of LysRS in mast cells

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Pathways of chaperone-mediated protein folding in the cytosol

Amyotrophic lateral sclerosis: a proposed mechanism.

P304

28321-28328

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scholarly article

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10.1074/JBC.M805599200

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42

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283

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2008-08-20T00:00:00Z

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18715867

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P932

2568925

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