Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
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A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKLHistone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorptionDietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of actionProtein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos inductiongp130 at the nexus of inflammation, autoimmunity, and cancer.Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection.Cells of the synovium in rheumatoid arthritis. Chondrocytes.Metalloproteases as potential therapeutic targets in arthritis treatment.The enigmatic cytokine oncostatin m and roles in diseaseProteinases involved in matrix turnover during cartilage and bone breakdown.Impact of inflammation on the osteoarthritic niche: implications for regenerative medicine.Potential directions for drug development for osteoarthritis.Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.A computer simulation approach to assessing therapeutic intervention points for the prevention of cytokine-induced cartilage breakdown.Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation.Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases.DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytesMetalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases.Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.A novel paradigm for dendritic cells as effectors of cartilage destruction.Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis.Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair.Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation.Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures
P2860
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P2860
Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
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name
Adenoviral gene transfer of in ...... oint damage in a murine model.
@en
Adenoviral gene transfer of in ...... oint damage in a murine model.
@nl
type
label
Adenoviral gene transfer of in ...... oint damage in a murine model.
@en
Adenoviral gene transfer of in ...... oint damage in a murine model.
@nl
prefLabel
Adenoviral gene transfer of in ...... oint damage in a murine model.
@en
Adenoviral gene transfer of in ...... oint damage in a murine model.
@nl
P2093
P2860
P1476
Adenoviral gene transfer of in ...... oint damage in a murine model.
@en
P2093
Andrew D Rowan
Carl D Richards
Tim E Cawston
P2860
P304
P356
10.1016/S0002-9440(10)64330-1
P407
P577
2003-06-01T00:00:00Z