V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a. - Wikidata - wikimedia - TriplyDB

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

http://www.wikidata.org/entity/Q42059658

about

Serrated polyposis: an enigmatic model of colorectal cancer predisposition Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance Genetics of the serrated pathway to colorectal cancer Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.Raf kinases in cancer-roles and therapeutic opportunities Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management A complex secretory program orchestrated by the inflammasome controls paracrine senescence.Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing.Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.Serrated polyps: critical precursors to colorectal cancer.Mechanisms of aneuploidy induction by RAS and RAF oncogenes Mechanisms of acquired resistance to ERK1/2 pathway inhibitors.Colorectal serrated pathway cancers and precursors.Serrated neoplasia-role in colorectal carcinogenesis and clinical implications.Langerhans cell histiocytosis is a neoplasm and consequently its recurrence is a relapse: In memory of Bob Arceci.Clinicopathological characteristics of serrated polyps as precursors to colorectal cancer: Current status and management.Senescent cells harbour features of the cancer epigenome.Sessile Serrated Adenomas: How to Detect, Characterize and Resect.TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer.CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies.A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans

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P2860

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

http://www.wikidata.org/entity/Q42059658

description

2010 nî lūn-bûn

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2010年の論文

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name

V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

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V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

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type

label

V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

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V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

@nl

prefLabel

V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

@en

V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

@nl

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EMBO Molecular Medicine

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V600EBraf induces gastrointest ...... d CpG methylation of p16INK4a.

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Bipin Patel

http://www.w3.org/2001/XMLSchema#string

Doug J Winton

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Kimberley R Snell

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Linda A S Carragher

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Susan M Giblett

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Victoria S S Aldridge

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P2860

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

Mutations of the BRAF gene in human cancer

Generalized lacZ expression with the ROSA26 Cre reporter strain

BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

Colorectal cancer and genetic alterations in the Wnt pathway

Guilty as charged: B-RAF is a human oncogene

Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors

Stem cells, self-renewal, and differentiation in the intestinal epithelium

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

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458-471

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10.1002/EMMM.201000099

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11

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2

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Catrin Pritchard

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47405058

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20941790

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3394506

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