Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
about
An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrualEmerging strategies to effectively target autophagy in cancerNucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and AutoinflammationExosomes maintain cellular homeostasis by excreting harmful DNA from cells.Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer.cGAS is essential for cellular senescence.AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- MiceOxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus.Activation and regulation of DNA-driven immune responses.The interplay between DNA repair and autophagy in cancer therapyCytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum.The emerging roles of the STING adaptor protein in immunity and diseases.Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology.Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy.The role of cGAS in innate immunity and beyond.Transplantation and Damage-Associated Molecular Patterns (DAMPs).Discriminating self from non-self in nucleic acid sensing.Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm.Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis.Lysosomal degradation of intracellular nucleic acids-multiple autophagic pathways.STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.Mitotic progression following DNA damage enables pattern recognition within micronuclei.cGAS surveillance of micronuclei links genome instability to innate immunity.TBC1D20 mediates autophagy as a key regulator of autophagosome maturation.cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity.Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues.Emerging roles of extracellular vesicles in cellular senescence and aging.Nuclear envelope rupture: little holes, big openings.Chromosomal instability drives metastasis through a cytosolic DNA response.Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.Telomere sequence content can be used to determine ALT activity in tumours.DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.
P2860
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P2860
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@en
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@nl
type
label
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@en
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@nl
prefLabel
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@en
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@nl
P2093
P2860
P1433
P1476
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
@en
P2093
Diana Londoño
Michael S Rooney
Richard Bouley
Yuk Yuen Lan
P2860
P304
P356
10.1016/J.CELREP.2014.08.074
P50
P577
2014-10-02T00:00:00Z