about
Synaptic function of nicastrin in hippocampal neuronsGenotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of MiceLong-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in miceTargets for AD treatment: conflicting messages from γ-secretase inhibitorsComputational drug repositioning through heterogeneous network clustering.Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β proteinPresenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.Oxidative stress and lipid peroxidation are upstream of amyloid pathology.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk.Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?Can animal skin diseases or current transgenic mice serve as a model for hidradenitis suppurativa?A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa.Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Genetics. Gamma-secretase and human disease.
@en
Genetics. Gamma-secretase and human disease.
@nl
type
label
Genetics. Gamma-secretase and human disease.
@en
Genetics. Gamma-secretase and human disease.
@nl
prefLabel
Genetics. Gamma-secretase and human disease.
@en
Genetics. Gamma-secretase and human disease.
@nl
P2860
P356
P1433
P1476
Genetics. Gamma-secretase and human disease.
@en
P2093
Raymond J Kelleher
P2860
P304
P356
10.1126/SCIENCE.1198668
P407
P577
2010-11-01T00:00:00Z