Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis
about
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcriptionPresenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Suppressor role of activating transcription factor 2 (ATF2) in skin cancerAmyloid precursor protein modulates beta-catenin degradationBeta-catenin: a transforming actor on many stagesSynaptic function of nicastrin in hippocampal neuronsAlzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared MechanismsΓ-secretase components as predictors of breast cancer outcomeLong-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in micePresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionImpaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient miceGamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activityHDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulinIdentification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafishFrom Alzheimer's disease to skin tumors: the catenin connection.Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trialsThe aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.Neddylation dysfunction in Alzheimer's disease.The γ-secretase complex: from structure to function.Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.Cell adhesion molecule regulation of nucleocytoplasmic trafficking.Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation.Presenilins regulate the cellular level of the tumor suppressor PTEN.Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutationFamilial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.Presenilin function and gamma-secretase activity.RNAi-mediated inhibition of presenilin 2 inhibits glioma cell growth and invasion and is involved in the regulation of Nrg1/ErbB signaling.Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis.Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skinLinking vascular disorders and Alzheimer's disease: potential involvement of BACE1Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer.The many faces of Notch signaling in skin-derived cells.
P2860
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P2860
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis
description
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2001
@ast
im September 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/09/11)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/09/11)
@nl
наукова стаття, опублікована у вересні 2001
@uk
name
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@ast
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@en
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@nl
type
label
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@ast
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@en
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@nl
prefLabel
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@ast
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@en
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@nl
P2093
P2860
P3181
P356
P1476
Loss of presenilin 1 is associ ...... gnaling and skin tumorigenesis
@en
P2093
A. M. Fletcher
S. Soriano
X. J. Wang
P2860
P304
10863–10868
P3181
P356
10.1073/PNAS.191284198
P407
P577
2001-09-11T00:00:00Z