Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. - Wikidata - wikimedia - TriplyDB

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

http://www.wikidata.org/entity/Q40083147

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Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7 Synaptic function of nicastrin in hippocampal neurons γ-Secretase inhibitors and modulators.Γ-secretase components as predictors of breast cancer outcome Modeling an anti-amyloid combination therapy for Alzheimer's disease.KSHV-induced notch components render endothelial and mural cell characteristics and cell survival.The secretases: enzymes with therapeutic potential in Alzheimer disease.Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.Central role of the EGF receptor in neurometabolic aging.Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.New pathway links γ-secretase to inflammation and memory while sparing notch.Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.Identification and characterization of five intramembrane metalloproteases in Anabaena variabilis.Role for Notch signaling in salivary acinar cell growth and differentiation Notch tumor suppressor function γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells.Neurogenesis and Alzheimer's disease: at the crossroads.Amyloid precursor protein processing and Alzheimer's disease Notch signalling in solid tumours: a little bit of everything but not all the time.Can animal skin diseases or current transgenic mice serve as a model for hidradenitis suppurativa?Crossing paths in Human Renal Cell Carcinoma (hRCC).Targeted next-generation sequencing identifies molecular subgroups in squamous cell carcinoma of the head and neck with distinct outcome after concurrent chemoradiation.Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways.A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.A Systematic Review and Critical Evaluation of Reported Pathogenic Sequence Variants in Hidradenitis Suppurativa.Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment.Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage.Arsenite suppresses Notch1 signaling in human keratinocytes [Hidradenitis suppurativa/acne inversa: An update].Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.Genetics. Gamma-secretase and human disease.EGFR signaling pathway and related-miRNAs in age-related diseases: the example of miR-221 and miR-222.American Association for Cancer Research Genetics and Biology of Brain Cancers 2009, December 13-15, 2009, San Diego, CA.[Acne inversa (hidradenitis suppurativa). From diagnosis to therapy].Hidradenitis suppurativa: haploinsufficiency of gamma-secretase components does not affect gamma-secretase enzyme activity in vitro.γ-Secretase gene mutations link acne inversa with Alzheimer's disease.

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P2860

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

http://www.wikidata.org/entity/Q40083147

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Epidermal growth factor recept ...... r function of gamma-secretase.

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type

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Epidermal growth factor recept ...... r function of gamma-secretase.

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Epidermal growth factor recept ...... r function of gamma-secretase.

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Journal of Biological Chemistry

P1476

Epidermal growth factor recept ...... r function of gamma-secretase.

@en

P2093

Abdul Fauq

http://www.w3.org/2001/XMLSchema#string

Barbara J Crain

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Cory Brayton

http://www.w3.org/2001/XMLSchema#string

Donald L Price

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Hongjin Wen

http://www.w3.org/2001/XMLSchema#string

Lisa A Smithson

http://www.w3.org/2001/XMLSchema#string

Philip C Wong

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Pritam Das

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Todd E Golde

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Tong Li

http://www.w3.org/2001/XMLSchema#string

P2860

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis.

Notch signaling: cell fate control and signal integration in development

A common human skin tumour is caused by activating mutations in beta-catenin

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

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32264-32273

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10.1074/JBC.M703649200

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P433

44

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282

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Charles G Eberhart

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2007-09-07T00:00:00Z

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P698

17827153

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