U2AF1 mutations alter splice site recognition in hematological malignancies. - Wikidata - wikimedia - TriplyDB

U2AF1 mutations alter splice site recognition in hematological malignancies.

U2AF1 mutations alter splice site recognition in hematological malignancies.

http://www.wikidata.org/entity/Q42088141

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Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping Emerging concepts of epigenetic dysregulation in hematological malignancies Aberrant splicing and drug resistance in AML Defective control of pre-messenger RNA splicing in human disease How do messenger RNA splicing alterations drive myelodysplasia?The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1 Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.RNA splicing factors as oncoproteins and tumour suppressors.Lessons from non-canonical splicing Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.What's different about atypical CML and chronic neutrophilic leukemia?Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations Somatic mutations predict outcomes of hypomethylating therapy in patients with myelodysplastic syndrome.Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations.RNA mis-splicing in disease.Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.DLX4 hypermethylation is a prognostically adverse indicator in de novo acute myeloid leukemia.Splicing-factor alterations in cancers.Therapeutic targeting of splicing in cancer.Splicing factor gene mutations in hematologic malignancies.RNA splicing during terminal erythropoiesis.Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.Widespread intron retention diversifies most cancer transcriptomes.Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies.Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.Modeling Myeloid Malignancies Using Zebrafish.The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5' splice site that impacts splicing regulation in Q157R patients.Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes.Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins.Insights from structures of cancer-relevant pre-mRNA splicing factors.Combined mutation and copy-number variation detection by targeted next-generation sequencing in uveal melanoma.

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P2860

U2AF1 mutations alter splice site recognition in hematological malignancies.

http://www.wikidata.org/entity/Q42088141

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name

U2AF1 mutations alter splice site recognition in hematological malignancies.

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U2AF1 mutations alter splice site recognition in hematological malignancies.

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type

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U2AF1 mutations alter splice site recognition in hematological malignancies.

@en

U2AF1 mutations alter splice site recognition in hematological malignancies.

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prefLabel

U2AF1 mutations alter splice site recognition in hematological malignancies.

@en

U2AF1 mutations alter splice site recognition in hematological malignancies.

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Genome Research

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U2AF1 mutations alter splice site recognition in hematological malignancies.

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Ahmad S Zebari

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Aravind Ramakrishnan

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Janine O Ilagan

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Michele E Murphy

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Philip Bradley

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Robert K Bradley

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P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Bioconductor: open software development for computational biology and bioinformatics

A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing

Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.

TopHat: discovering splice junctions with RNA-Seq

DNMT3A Mutations in Acute Myeloid Leukemia

Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d

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