Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV
about
Structural basis of gate-DNA breakage and resealing by type II topoisomerasesStructure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transportImpact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistanceExploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesFluoroquinolone-gyrase-DNA complexes: two modes of drug binding.Challenges of antibacterial discoveryRole of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridgeBypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae.Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Protective effect of Qnr on agents other than quinolones that target DNA gyrase.Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.New antibiotic agents in the pipeline and how they can help overcome microbial resistance.Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.Mechanism of quinolone action and resistance.Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana.Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases.Impact of the E540V amino acid substitution in GyrB of Mycobacterium tuberculosis on quinolone resistanceComparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities.DNA Topoisomerases as Targets for Antibacterial Agents.A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.
P2860
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P2860
Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Probing the differential inter ...... th gyrase and topoisomerase IV
@en
Probing the differential inter ...... th gyrase and topoisomerase IV
@nl
type
label
Probing the differential inter ...... th gyrase and topoisomerase IV
@en
Probing the differential inter ...... th gyrase and topoisomerase IV
@nl
prefLabel
Probing the differential inter ...... th gyrase and topoisomerase IV
@en
Probing the differential inter ...... th gyrase and topoisomerase IV
@nl
P2093
P2860
P356
P1476
Probing the differential inter ...... th gyrase and topoisomerase IV
@en
P2093
Katherine A Gould
L Mark Fisher
Xiao-Su Pan
P2860
P304
P356
10.1128/AAC.00113-09
P407
P577
2009-06-29T00:00:00Z