Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase.
about
Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expressionCyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoterCharacterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D geneIdentification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructsThe human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipramThe human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domainsThe unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domainsGenomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domainsAssociation with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibitionIdentification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variantsTAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acidStriatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10AThe SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationCharacterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitorsIntracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines.Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase.Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family.Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.
P2860
Q22254649-0EC75574-DEC1-432E-B2DE-374DDCF3CA06Q24301633-9AA98ED4-C2F1-4102-9AEE-96349440F77BQ24308220-3D52338A-089B-4D5A-B52C-0C995906E9ECQ24317630-193C4EA0-B2EE-4080-8BFC-8CE4C3C586BDQ24530596-B55C4031-1717-4141-9B3A-61409C3F5B9AQ24533566-BD8295BD-5BFD-42B7-9839-FCEC3DE79F7FQ27732838-454695D9-E917-484E-9CC1-C890E3DC2EF9Q28115926-66DEA1BD-103B-4415-88E6-1A2AF00659A1Q28116175-B278067F-F4F2-4F9C-9D42-B1EB6F768B4BQ28138448-1B322210-8AF1-4653-85BF-4EAE40D8841BQ28140572-F10C869C-6AF1-4D2F-969E-756E2EF8E857Q28141780-8F5ED7F3-A574-429A-8834-CF3BD1B1D418Q28212447-57480435-9066-4259-85F9-C60007C9E63BQ28216705-A6144BD9-8B21-4AE5-9FD3-5EA9305B68CFQ28574633-39B3DEA6-1D5C-498A-A4E0-15171EF2478FQ30176855-9E233EAE-8558-4764-9FA9-044951CDAC1BQ35005680-F5B8EE32-466B-45E9-92B2-F78CF2AD883DQ35027541-35D148BB-FEC7-4DE4-9495-4842AB3C5D83Q36843124-4EACC7E8-04CB-490A-BDBB-042C0DEFFCE8Q37041337-819434F1-8B5F-488C-8BC6-1FD3FA26CA07Q37401396-57AAD93D-448A-4C26-B94D-B6F6AD7C386CQ37947681-7F9BEEEC-9502-4315-88F8-1283AB6D149FQ38332843-590C8547-87CE-4986-9726-486721DCEA30Q41295240-DBEE87ED-363B-4281-BAA3-DD8CD4743581Q42117582-A46F85E8-B20E-4AC4-AA30-5362ACE10BD0Q47945962-92459CB8-C1B8-4EB5-A066-4B3E3C64BEC6
P2860
Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Chimeric constructs show that ...... ramphenicol acetyltransferase.
@en
Chimeric constructs show that ...... clic AMP phosphodiesterase RD1
@nl
type
label
Chimeric constructs show that ...... ramphenicol acetyltransferase.
@en
Chimeric constructs show that ...... clic AMP phosphodiesterase RD1
@nl
prefLabel
Chimeric constructs show that ...... ramphenicol acetyltransferase.
@en
Chimeric constructs show that ...... clic AMP phosphodiesterase RD1
@nl
P2860
P356
P1433
P1476
Chimeric constructs show that ...... ramphenicol acetyltransferase.
@en
P2093
G Scotland
P2860
P304
P356
10.1042/BJ3080673
P407
P478
308 ( Pt 2)
P577
1995-06-01T00:00:00Z