Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. - Wikidata - wikimedia - TriplyDB

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

http://www.wikidata.org/entity/Q37041337

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Treating brain tumors with PDE4 inhibitors Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis An integrative view on sex differences in brain tumors Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: an Italian multi-institutional phase II trial.Growth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule.PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma Identification of novel genetic alterations in samples of malignant glioma patients.Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions Targeting brain tumor cAMP: the case for sex-specific therapeutics Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model.Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation.A novel murine model for localized radiation necrosis and its characterization using advanced magnetic resonance imaging.Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy.Regulation of the Hippo pathway and implications for anticancer drug development.Targeting cancer with phosphodiesterase inhibitors.Clinical and molecular genetics of the phosphodiesterases (PDEs).Current and emerging molecular targets in glioma.Molecular imaging coupled to pattern recognition distinguishes response to temozolomide in preclinical glioblastoma.Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies.Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclea The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes.Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer.Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest.CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.Protein kinase a in cancer Targeted activation of PKA and Epac promotes glioblastoma regression in vitro Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1 The Role of Protein Kinase B Signaling Pathway in Anti-Cancer Effect of Rolipram on Glioblastoma Multiforme: An In Vitro Study.Head and neck cancers, the neglected malignancies: present and future treatment strategies.Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo.

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Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

http://www.wikidata.org/entity/Q37041337

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on December 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

@en

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

@nl

type

label

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

@en

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

@nl

prefLabel

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

@en

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

@nl

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1078-0432.CCR-08-0827

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Clinical Cancer Research

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Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

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Andrew Hope

http://www.w3.org/2001/XMLSchema#string

Arie Perry

http://www.w3.org/2001/XMLSchema#string

B Mark Woerner

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David D Limbrick

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David Piwnica-Worms

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Erin Jackson

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Joshua B Rubin

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Nicole M Warrington

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Patricia Goldhoff

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P2860

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

MGMT gene silencing and benefit from temozolomide in glioblastoma.

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

Keynote review: phosphodiesterase-4 as a therapeutic target

CXCR4 regulates growth of both primary and metastatic breast cancer

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy.

Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.

The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.

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7717-7725

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10.1158/1078-0432.CCR-08-0827

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23

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2008-12-01T00:00:00Z

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