Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL.
about
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapiesDangER: protein ovERload. Targeting protein degradation to treat myelomaXenobiotic perturbation of ER stress and the unfolded protein responseFirst siRNA library screening in hard-to-transfect HUVEC cells.Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells.Endoplasmic reticulum stress and cancer.Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabineA review of the mammalian unfolded protein response.The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinibToxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A.Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism.Endoplasmic reticulum stress in disease pathogenesisMyc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.The molecular characterization and clinical management of multiple myeloma in the post-genome era.Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.SAC1 lipid phosphatase and growth control of the secretory pathway.ER-Golgi network--a future target for anti-cancer therapy.Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cellsActivation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.The use of molecular-based risk stratification and pharmacogenomics for outcome prediction and personalized therapeutic management of multiple myeloma.Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus.Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy.Risk Stratification in Multiple Myeloma.Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.Brefeldin a induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits focal adhesion kinase-mediated cell invasion.Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling.Necrosis induction in glioblastoma cells reveals a new "bioswitch" function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus cell death decision.DHMEQ, a new NF-kappaB inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells.The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments.The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomibReovirus therapy stimulates endoplasmic reticular stress, NOXA induction, and augments bortezomib-mediated apoptosis in multiple myeloma.γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation.Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas.The phospholipase DDHD1 as a new target in colorectal cancer therapy.Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review
P2860
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P2860
Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@en
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@nl
type
label
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@en
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@nl
prefLabel
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@en
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@nl
P2093
P2860
P1433
P1476
Targeting endoplasmic reticulu ...... fludarabine resistance in CLL.
@en
P2093
David J McConkey
Jennifer S Carew
Kenneth Dunner
Peng Huang
Steffan T Nawrocki
Yelena V Krupnik
P2860
P304
P356
10.1182/BLOOD-2005-05-1923
P407
P577
2005-09-06T00:00:00Z