Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

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MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.eModel-BDB: a database of comparative structure models of drug-target interactions from the Binding Database

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Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Charged Propargyl-Linked Antif ...... Clinically Relevant Mutations.

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Amy C Anderson

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Eric Scocchera

http://www.w3.org/2001/XMLSchema#string

Jacob J Ferreira

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Narendran G-Dayanandan

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Santosh Keshipeddy

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P2860

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim

Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase

Predicting resistance mutations using protein design algorithms

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

Coot: model-building tools for molecular graphics

Solving structures of protein complexes by molecular replacement with Phaser

Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).

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scholarly article

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10.1021/ACS.JMEDCHEM.6B00688

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Dennis L Wright

Stephanie Reeve

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2016-06-16T00:00:00Z

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27308944

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Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

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P2860

P2860

Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.

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