Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes
about
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among speciesExploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPKElucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate ReductasePropargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrataPropargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosisThe Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.Blue light eliminates community-acquired methicillin-resistant Staphylococcus aureus in infected mouse skin abrasionsCrystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.Protein design algorithms predict viable resistance to an experimental antifolateProspective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistanceAcetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.Antifolate agents: a patent review (2010 - 2013).Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.
P2860
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P2860
Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@ast
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@en
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@nl
type
label
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@ast
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@en
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@nl
altLabel
Toward new therapeutics for sk ...... RSA and Streptococcus pyogenes
@en
prefLabel
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@ast
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@en
Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@nl
P2093
P2860
P3181
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Toward New Therapeutics for Sk ...... RSA and Streptococcus pyogenes
@en
P2093
Amy C Anderson
Brooke D Martin
Dennis L Wright
Eric W Scocchera
Jeremy B Alverson
Kathleen M Frey
Kishore Viswanathan
Nigel D Priestley
P Whitney Swain Iii
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0029434
P407
P577
2012-01-01T00:00:00Z