about
Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase functionStructure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate ReductaseSynthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate ReductaseProbing the Active Site ofCandida glabrataDihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New InhibitorsCrystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim ResistanceStructural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among speciesElucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate ReductasePropargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrataEfficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosisNatural products in parallel synthesis: triazole libraries of nonactic acid.Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.Antifolate agents: a patent review (2006 - 2010).Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistanceNonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determinationTowards new antifolates targeting eukaryotic opportunistic infectionsInhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.Antifolate agents: a patent review (2010 - 2013).Antibacterial Antifolates: From Development through Resistance to the Next GenerationThe challenge of resistance in antimicrobial drug development.Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sitesIn vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.Bicyclo[3.2.1]octane synthons from cyclopropenes: functionalization of cycloadducts by nucleophilic additions.Bridged synthons from tetrabromocyclopropene: studies on the rearrangement of the primary Diels-Alder adduct with 2,5-dimethylfuran.New chiral building blocks from tetrabromocyclopropene and furan.The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings.The tandem ring opening/ring closing metathesis route to oxaspirocycles: an approach to phelligridin G.Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells.USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.
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P50
description
researcher
@en
wetenschapper
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հետազոտող
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name
Dennis L Wright
@ast
Dennis L Wright
@en
Dennis L Wright
@es
Dennis L Wright
@nl
type
label
Dennis L Wright
@ast
Dennis L Wright
@en
Dennis L Wright
@es
Dennis L Wright
@nl
prefLabel
Dennis L Wright
@ast
Dennis L Wright
@en
Dennis L Wright
@es
Dennis L Wright
@nl
P106
P1153
12808350300
P21
P31
P496
0000-0003-4634-3351